By MyFM's Rick Michaels - A joint federal and state investigation targeting narcotics trafficking in Central Massachusetts culminated yesterday with ten people being charged. Assisting with the investigation was several police chiefs from the area including Milford Police Chief Tom O’Loughlin. Three Lawrence men and a Leominster man were taken into custody and two were brought to federal court in Worcester, charged with conspiring to distribute and possess in excess of 100 grams of Heroin and Fentanyl. The other two men will head to court today to face the same charges. Six additional individuals have been charged with various drug offenses including four residents of Worcester and a woman from Shirley. The Massachusetts Attorney General's Office says one defendant remains at large at this time. The investigation involved various wiretaps capturing the discussion of sales and purchases of Heroin and Fentanyl during November and December of last year. Milford Police Chief Tom O’Loughlin along with police chiefs from Worcester, Leominster and Leicester assisted State Police and federal authorities with the investigation.